DOXAZOSIN MESYLATE

DOXAZOSIN MESYLATE
PRODUCT IDENTIFICATION
CAS NO.	77883-43-3
EINECS NO.
FORMULA	C₂₃H₂₅N₅O₅·CH₃SO₃H
MOL WT.	547.58
H.S. CODE	2934.90
TOXICITY
SYNONYMS	Doxazosin mesylate;
1-(p-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl) carbonyl)] piperazine monomethanesulfonate; 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)-4-[ 4-(1,4-benzodioxan-2-yl) carpiperazin-1-yl)]-6,7-dimethoxyquinazoline mesylate
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Slightly soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
GENERAL DESCRIPTION & APPLICATIONS
doxazosin mesylate, a quinazoline derivative, is an alpha1-receptor antagonist used as an antihypertensive agent which blocks of alpha1-adrenergic receptors and has a longer half life than that of prazosin. The chemical designation 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-yl carbonyl) piperazine methanesulfonate. It is a white to off-white crystalline powder; slightly soluble in water, alcohols; soluble in dimethylsulfoxide, dimethylformamide ands acetic acid; insoluble in acetone and methylene chloride.
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
ASSAY	99.0% min (HPLC)
WATER	0.2% max
LOSS ON DRYING	0.5% max
TOTAL IMPURITY	1.0% max
HEAVY METALS	10ppm max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
PRICE INFORMATION